| CAS NO: | 42971-09-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 350.45 |
|---|---|
| Formula | C22H26N2O2 |
| CAS No. | 42971-09-5 (Vinpocetine); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 3 mg/mL (8.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: ethyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate InChi Key: DDNCQMVWWZOMLN-IRLDBZIGSA-N InChi Code: InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1 SMILES Code: O=C(C1=C[C@@](CCC2)(CC)[C@]3([H])N2CCC4=C3N1C5=C4C=CC=C5)OCC |
| Synonyms | RGH-4405; TCV 3B, apovincaminic acid ethyl ester, ethyl apovincaminate, AY 27,255, RGH 4405, TCV-3B, AY-27,255, RGH4405, TCV3B, Cavinton, Intelectol |
| In Vitro | In vitro activity: Vinpocetine has been reported to have a selective and noncompetitive inhibition of Ca2+ PDE and thus regulate cyclic GMP levels in smooth muscle. In addition, vinpocetine has been revealed to inhibit the activities of three resolvable PDE in the cytosol of rat aorta with Ki values of 14±2μM,>1000μM and>1000μM for Ca2+ PDE(+)CaM, cGMP PDE and cAMP PDE, respectively. Cell Assay: Vinpocetine (Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels. |
|---|---|
| In Vivo | Vinpocetine has shown the potent inhibition of 5-HT-induced contractions in endothelium-intact rat aorta with an EC50 value of 1μM. |
| Animal model | Rats |
| Formulation & Dosage | N/A |
| References | Br J Pharmacol. 1989 Nov;98(3):725-34. |
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