CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.

388086-13-3

C21H14Cl2N2O2

397.25

CAY10722

Ethanol:Slightly soluble
DMF:10 mg/mL
DMSO:PBS(pH7.2) (1:1):0.5 mg/mL
DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years