NAMPT-IN-8 (Compound 10d) 是一种NAMPT抑制剂，IC50值为 0.183 μM。NAMPT-IN-8 也是一种比较好的 NQO1 底物。NAMPT-IN-8 诱导Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis) 和活性氧 (ROS) 产生。

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC 50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS [1].

Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC 50 of 1.15 μM [1].

Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity [1].

2453183-75-8

C36H35N3O4

573.68

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years