PF-06761281 (Compound 4a) 是一种有效的、具有口服活性的、部分选择性钠偶联柠檬酸转运蛋白 (NaCT/SLC13A5) 抑制剂，对 HEKNaCT、 HEKNaDC1和 HEKNaDC3的IC50值分别为 0.51, 13.2 和 14.1 μM。

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC 50 values of 0.51, 13.2 and 14.1 μM against HEK NaCT, HEK NaDC1 and HEK NaDC3, respectively [1].

PF-06761281 (Compound 4a) inhibits citrate uptake with IC 50 values of 0.12, 0.21 and 0.74 μM in rat, mouse and human Heps [1].

1854061-19-0

C13H17NO6

283.28

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years