BB-Cl-Amidine hydrochloride is an inhibitor peptidyl arginine deminase (PAD).

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. The BB-Cl-amidine group also shows a strong trend towards the downregulation of IRGs. Treatment with BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely.

T10482L

C26H27Cl2N5O

496.43

BB-Cl-Amidine hydrochloride (1802637-39-3 free base);BB-Cl-Amidine hydrochloride

DMSO:100 mg/mL (201.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years