BSc5367 是一种有效的Nek1抑制剂，IC50为 11.5 nM。NIMA 相关蛋白激酶 Nek1 参与细胞周期调节、DNA 修复和微管调节，Nek1 的功能失调在肌萎缩侧索硬化症 (ALS)、多囊肾病 (PKD) 和几种抗放疗癌症中起关键作用。

BSc5367 is a potent Nek1 inhibitor with an IC 50 of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer [1].

C20H15N3O2

329.35

(< 1 mg/ml refers to the product slightly soluble or insoluble )
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In solvent: -80°C for 2 years