FTO-IN-8 (FTO-43) 是一种 N6-甲基腺苷去甲基化酶 (FTO) (脂肪量和肥胖相关蛋白) 抑制剂，IC50值为 5.5 μM，具有抗癌细胞增殖活性。

FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase ( FTO ) (fat mass- and obesity-associated protein) inhibitor with the IC 50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity [1].

FTO-IN-8 (FTO-43) (0-50 μM, 24-72 h) inhibits the proliferation of cancer cells with no cytotoxicity to normal colonic cells [1]. FTO-IN-8 (FTO-43) can increase m 6 A and m 6 A m levels and inhibits Wnt/PI3K-Akt signaling in gastric cancer AGS cells [1]. Cell Viability Assay [1] Cell Line: AGS, SNU16, and KATOIII cell lines Concentration: 0-50 μM Incubation Time: 24, 48, 72 hours Result: Inhibited the growth of SNU16, KATOIII and AGS with the EC 50 values of 17.7 μM, 35.9 μM and 20.3 μM, respectively.

2640366-38-5

C19H23ClN2O2

346.85

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years