CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC50 值为 3 nM。

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

CDK8-IN-1 displays low systemic clearance, very good exposure, and oral bioavailability. The tmax is 0.25 h by p.o. The values of AUC are 9378, 25952 by i.v., and p.o. respectively. The mean values of Cmax are 9940 μg/L, 12740 μg/L by i.v., and p.o. respectively[1].

1629633-48-2

C11H8F3N3O

255.20

CDK8-IN-1

DMSO:90mg/mL (352.7mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years