SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].

627052-25-9

C22H38N2O

346.55

SQ609

DMSO:6.67 mg/mL (19.25 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years