DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants.

In vivo, DPC-AJ1951 normalizes serum calcium levels in thyroidparathyroidectomized rats.

DPC-AJ1951 (trifluoroacetate salt);DPC-AJ1951 (trifluoroacetate salt)

H2O:Slightly soluble
DMSO:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years