KIF18A-IN-4 是一种中度有效的 ATP 和微管 (microtubule) 非竞争性KIF18A抑制剂 (IC50=6.16 μM)。KIF18A-IN-4 对大量有丝分裂驱动蛋白和激酶具有选择性，对微管蛋白组装没有任何直接影响。具有抗肿瘤活性。

KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor ( IC 50 =6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity [1].

KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+) [1]. KIF18A-IN-4 (0-10 μM; overnight) has an EC 50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay [1].

1197522-21-6

C22H27N3O3S

413.54

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years