BTB06584

立即咨询

BTB06584

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	219793-45-0
规格:	≥98%

包装与价格：

包装	价格(元)
5mg	电议
50mg	电议
100mg	电议
250mg	电议
500mg	电议

产品介绍

BTB06584 (BTB-06584; BTB 06584) is a novel, potent and IF1-dependent inhibitor of the mitochondrial F1 Fo-ATPase, acting by selectively inhibiting mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase.

理化性质和储存条件

Molecular Weight (MW)	417.82
Formula	C19H12ClNO6S
CAS No.	219793-45-0
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 84 mg/mL (201.0 mM)
	Water: <1 mg/mL
	Ethanol: <1 mg/mL
Other info	Chemical Name: 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate InChi Key: WNDWKKPBLAKXMI-UHFFFAOYSA-N InChi Code: InChI=1S/C19H12ClNO6S/c20-14-8-6-13(7-9-14)19(22)27-18-12-16(10-11-17(18)21(23)24)28(25,26)15-4-2-1-3-5-15/h1-12H SMILES Code: O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O
Synonyms	BTB06584; BTB 06584; BTB-06584

实验参考方法

In Vitro	In vitro activity: BTB06584 IF1-dependently inhibits F1 Fo-ATPase activity with no effect on without compromising ATP synthesis, and also limits ischemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATP synthase. Cell Assay: BTB inhibited F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm) or O2 consumption. ATP consumption decreased via inhibition of respiration, and ischaemic cell death was reduced. BTB efficiency increased by IF1 overexpression and reduced by silencing this protein. In addition, BTB rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.
In Vivo	BTB06584 rescues the defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants without causing significant toxicity.
Animal model	zebrafish pinotage
Formulation & Dosage	N/A
References	Br J Pharmacol. 2014 Sep;171(18):4193-206.