| CAS NO: | 1383716-46-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
Molecular Weight (MW) | 391.47 |
Formula | C21H25N7O |
CAS No. | 1383716-46-8 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 78 mg/mL (199.2 mM) |
Water: <1 mg/mL | |
Ethanol: <1 mg/mL | |
SMILES Code | CC(C)(O)CNC1=NC=C(C2=CC=NC(NC3=CC=NC(Cl)=C3)=N2)C(CC4CC4)=N1 |
Synonyms | Vps34-IN1, Compound 19, PIK-III analogue |
In Vitro | In vitro activity: VPS34 inhibitor 1 (Vps34-IN1, Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 induces a rapid dose-dependent dispersal of a specific PtdIns-(3)-P-binding probe from endosome membranes, within one minute, without affecting the ability of class I PI3K to regulate Akt. |
In Vivo | |
Animal model | |
Formulation & Dosage | |
References | ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. |
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