MD-224 is a novel, first-in-class and potent PROTAC molecule targeting human murine double minute 2 (MDM2) for degradation, it has the potential to be used as a new class of anticancer agent. It is able to induce rapid degradation of MDM2 protein at a concentration of<1 nM in human leukemia cells, and has an antiproliferative IC50 value of 1.5 nM for inhibiting the growth of RS4;11 cells.

纯度：≥98%

CAS：2136247-12-4