西帕加明(Cipargamin,1193314-23-6) has been used in trials studying the treatment of Malaria, Cure Rate, and Plasmodium Falciparum Malaria.
| 中文别名 | 西帕加明(Cipargamin,1193314-23-6)(1'R,3'S)-5,7'-二氯-6'-氟-2',3',4',9'-四氢-3'-甲基螺[3H-吲哚-3,1'-[1H]吡啶并[3,4-B]吲哚]-2(1H)-酮 |
| 英文别名 | Cipargamin(西帕加明,1193314-23-6) |
| CAS号 | 1193314-23-6 |
| SMILES | FC1=C(Cl)C=C(NC2=C3C[C@H](C)N[C@@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1 |
| Inchi | InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1 |
| InchiKey | CKLPLPZSUQEDRT-WPCRTTGESA-N |
| 分子式 Formula | C19H14Cl2FN3O |
| 分子量 Molecular Weight | 390.24 |
| 闪点 FP | 329.6±31.5 ℃ |
| 沸点 Boiling point | 621.3±55.0 ℃ at 760 mmHg |
| Polarizability极化度 | 39.3±0.5 10-24cm3 |
| 密度 Density | 1.6±0.1 g/cm3 |
| 蒸汽压 Vapor Pressure | 0.0±1.8 mmHg at 25℃ |
| 溶解度Solubility | 生物体外In Vitro:DMSO溶解度50 mg/mL(128.13 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble) |
| 性状 | 固体粉末,Power |
| 储藏条件 Storage conditions | -20℃ 3 years年 4℃ 2 years年 / In solvent溶液中:-80℃ 6 months月 -20℃ 1 month月 |
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