IPTBC is an inhibitor of the antiapoptotic Bcl-2 protein by acting as a BH3 mimetic. IPTBC exhibits dose-dependent cytotoxicity in breast adenocarcinoma (MCF-7) cells. References: Kamath PR, Sunil D, Joseph MM, Abdul Salam AA, T T S. Indole-coumarin-thiadiazole hybrids: An appraisal of their MCF-7 cell growth inhibition, apoptotic, antimetastatic and computational Bcl-2 binding potential. Eur J Med Chem. 2017 Aug 18;136:442-451. doi: 10.1016/j.ejmech.2017.05.032. Epub 2017 May 11. PubMed PMID: 28525842.
纯度:≥98%