PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig cerebral cortex & gastric mucosa in the central and peripheral nervous systems. References: Hunter JC, Suman-Chauhan N, Meecham KG, Dissanayake VU, Hill DR, Pritchard MC, Kneen CO, Horwell DC, Hughes J, Woodruff GN. [3H]PD 140376: a novel and highly selective antagonist radioligand for the cholecystokininB/gastrin receptor in guinea pig cerebral cortex and gastric mucosa. Mol Pharmacol. 1993 Apr;43(4):595-602. PubMed PMID: 8474432. 2: Harper EA, Griffin EP, Shankley NP, Black JW. Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1496-503. PubMed PMID: 10217545; PubMed Central PMCID: PMC1565919. 3: Pinnock RD, Suman-Chauhan N, Daum P, Hill DR, Woodruff GN. The cholecystokinin-induced increase in intracellular calcium in AR42J cells is mediated by CCKB receptors linked to internal calcium stores. Neuropeptides. 1994 Sep;27(3):175-83. PubMed PMID: 7816188. 4: Harper EA, Shankley NP, Black JW. Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1504-12. PubMed PMID: 10217546; PubMed Central PMCID: PMC1565918. 5: Suman-Chauhan N, Meecham KG, Webdale L, Hunter JC, Pritchard MC, Woodruff GN, Hill DR. The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B/gastrin receptors: binding studies using [3H]PD140376. Regul Pept. 1996 Aug 27;65(1):37-43. PubMed PMID: 8876034.

纯度：≥98%

CAS：149027-97-4