生物活性
CHIR-090是一种有效，缓慢，亲和力强的 LpxC 脱乙酰酶抑制剂。它与 E. coli LpxC 结合的 Ki 值为 4.0 nM。
化学数据
| 目录号 | A12365 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 437.49 |
| Formula | C24H27N3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 728865-23-4 |
| Synonyms | CHIR090, CHIR 090 |
| SMILES | C[C@H]([C@@H](C(=O)NO)NC(=O)C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)O |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.86 mL | 114.29 mL | 228.58 mL |
| 0.5 mM | 4.57 mL | 22.86 mL | 45.72 mL |
| 1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
*The above data is based on the productmolecular weight 437.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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