生物活性
Cilengitide是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性，从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。
化学数据
| 目录号 | A12372 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 588.66 |
| Formula | C27H40N8O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 188968-51-6 |
| Synonyms | EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497 |
| SMILES | CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.99 mL | 84.94 mL | 169.88 mL |
| 0.5 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 1 mM | 1.7 mL | 8.49 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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