生物活性
SR 144528是一种选择性的外周大麻素受体反向激动剂，对大鼠脾脏和人重组CB2受体的Ki值为0.6 nM，对大鼠脑和人重组CB1受体的Ki值为400 nM。
化学数据
| 目录号 | A12376 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 476.05 |
| Formula | C29H34ClN3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 192703-06-3 |
| Synonyms | SR144528, SR-144528 |
| SMILES | CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)N[C@H]3[C@]4(CC[C@H](C4)C3(C)C)C)C5=CC(=C(C=C5)Cl)C |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.01 mL | 105.03 mL | 210.06 mL |
| 0.5 mM | 4.2 mL | 21.01 mL | 42.01 mL |
| 1 mM | 2.1 mL | 10.5 mL | 21.01 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
*The above data is based on the productmolecular weight 476.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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