(-)-PX20606transisomer是一种FXR激动剂,在FRET和M1H测定中对于FXR的EC50值分别为18和29nM。
CAS:1268244-88-7
分子式:C29H22Cl3NO4
分子量:554.85
纯度:98%
存储:Store at -20°C
Background:
(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.