BPN14770 是一种选择性磷酸二酯酶 4D (PDE4D) 变构抑制剂，对于 PDE4D7 与 PDE4D3 的 IC50 值分别为 7.8 nM 和 7.4 nM。
CAS：1606974-33-7
分子式：C21H15ClF3NO2
分子量：405.8
纯度：98%
存储：Store at -20°C

Background:

BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1]. PDE4D3|7.4 nM (IC50)|PDE4D7|7.8 nM (IC50)

BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2]. Animal Model: C57Bl6 mice[2]

[1]. Ricciarelli R, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. Sci Rep. 2017 Apr 12;7:46320. [2]. Gurney ME, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019 May 23;62(10):4884-4901.