T338CSrc-IN-1是突变型c-SrcT338C高效抑制剂,IC50值111nM。对WTSrc活性弱10倍以上。
CAS:1351926-90-3
分子式:C17H20N6O2S
分子量:372.44
纯度:98%
存储:Store at -20°C
Background:
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).
[1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15046-52.