TH 1020 是一种有效的选择性 toll 样受体 5 (TLR5)/鞭毛蛋白复合物拮抗剂，IC50 为 0.85 μM。
货号:ajcx27442
CAS:1841460-82-9
分子式:C23H15N7S2
分子量：453.54
溶解度:Chloroform: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID:26634412