K-Ras ligand-Linker Conjugate 3 (Compound 001371) 包含靶蛋白 K-Ras 配体 (K-Ras 募集基序) 和 PROTAC linker，可募集 E3 连接酶 (如 VHL，CRBN，MDM2 和 IAP 等类型)。K-Ras ligand-Linker Conjugate 3 可广泛用于 PROTAC 介导的蛋白降解。
货号:ajcx16156
CAS:2378261-87-9
分子式:C49H65N7O10S
分子量：944.15
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for FAK (a KRas recruiting moiety), and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be extensively used for PROTAC-mediated protein degradation[1].

[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.