FOY251是camostate的抗蛋白水解活性代谢物，能作为蛋白酶(proteinase)抑制剂。FOY251在细胞实验中能抑制SARS-CoV-2的感染。
货号:ajcx30680
CAS:71079-09-9
分子式:C17H19N3O7S
分子量：409.41
溶解度:DMSO: 20 mg/mL (48.85 mM; ultrasonic and adjust pH to 5 with HCl); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FOY 251 is an anti-proteolytic active metabolite camostate , acts as a proteinase inhibitor[1][2].FOY 251 inhibit SARS-CoV-2 infection in cells assay[1][3].

FOY-251 represents a dose-dependent inhibition of equivalent current in M-1 cells[2].FOY-251 inhibits the proteolytic activity of prostasin[2].

[1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651.