K-Ras G12C-IN-4，化合物 1，是 KRASG12C 的有效共价抑制剂。
货号:ajcx34088
CAS:2376328-55-9
分子式:C31H33ClN4O4
分子量：561.07
溶解度:DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].

K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1].K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].

[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.