An indole alkaloid with analgesic activity
货号:ajcx26214
CAS:3512-87-6
分子式:C22H26N2O4
分子量：382.5
溶解度:DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Akuammine is an indole alkaloid that has been found inPicralima nitidaand has analgesic activity.¹It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (K_is = 0.3, 1.68, and 10.4 µM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC₅₀s = 2.6 and 0.073 µM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

1.Creed, S.M., Gutridge, A.M., Argade, M.D., et al.Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloidsJ. Nat. Prod.84(1)71-80(2021)