A PD-1/PD-L1 interaction inhibitor
货号:ajcx24022
CAS:N/A
分子式:C26H25Br2NO3
分子量：559.3
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC₅₀= 15 nM in a homologous time-resolved fret (HTRF) assay).¹It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC₅₀= 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4⁺and CD8⁺T cells co-cultured with aAPCs.

1.Konieczny, M., Musielak, B., Kocik, J., et al.Di-bromo-based small-molecule inhibitors of the PD-1/PD-L1 immune checkpointJ. Med. Chem.63(19)11271-11285(2020)