An internal standard for the quantification of thromboxane B2d4
货号:ajcx23608
CAS:1346112-79-5
分子式:C20H30D4O6
分子量：374.5
溶解度:DMF: >50 mg/ml (from TXB2),DMSO: >25 mg/ml (from TXB2),Ethanol: >100 mg/ml (from TXB2),PBS pH 7.2: >100 μg/ml (from TXB2)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thromboxane B₂-d₄(TXB₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of TXB₂by GC-or LC-mass spectrometry. TXB₂is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA₂, which has a half-life of about 30 seconds.¹Urinary analysis of TXB₂accurately reflects intrarenal TXA₂synthesis,²while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA₂secretion.^3,4

1.Needleman, P., Moncada, S., Bunting, S., et al.Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxidesNature261(5561)558-560(1976) 2.Patrono, C., Ciabattoni, G., Patrignani, P., et al.Evidence for a renal origin of urinary thromboxane B2 in health and diseaseAdv. Prostaglandin Thromboxane Leukot. Res.11493-498(1983) 3.Lawson, J.A., Patrono, C., Ciabattoni, G., et al.Long-lived enzymatic metabolites of thromboxane B2 in the human circulationAnal. Biochem.155(1)198-205(1986) 4.Patrono, C., Ciabattoni, G., Pugliese, F., et al.Estimated rate of thromboxane secretion into the circulation of normal humansJ. Clin. Invest.77(2)590-594(1986)