SJ10542 是一种有效的选择性 JAK2/3 导向苯基戊二酰亚胺 (PG)-PROTAC，对 JAK2、JAK3 和 JAK2-fusion ALL 的 DC50 分别为 14、11 和 24 nM。SJ10542 利用PG 配体作为 cereblon (CRBN) 招募剂。
货号:ajcx37666
CAS:N/A
分子式:C41H46N12O5S
分子量：818.95
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter[1].

[1]. Lisa J.Alcock,et al. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.ACS Med.Chem.Lett.2022,13,3,475-482.