Gambogenic acid 是黄藤中的有效成分，具有抗癌活性。Gambogenic acid 为有效的 EZH2 抑制剂，特异性地与 EZH2-SET 结构域的 Cys668 位点共价结合，诱导 EZH2 泛素化。
货号:ajcx14252
CAS:173932-75-7
分子式:C38H46O8
分子量：630.77
溶解度:DMSO: 250 mg/mL (396.34 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1].

[1]. Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260.