(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) 是 FL118 的 R 型异构体。(R)-FL118 具有抗癌 (anticancer) 活性。
货号:ajcx39474
CAS:151636-76-9
分子式:C21H16N2O6
分子量：392.36
溶解度:DMSO : 2.7 mg/mL (6.88 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 . (R)-FL118 shows anticancer activity[1].

(R)-FL118 inhibits the growth of melanoma, breast, and prostate cancer cell lines, with IC50 values of 392.7, 32.53, 129.3, 138.7, and 92.51 ng/mL in B16, MCF-7, HS578T, DU145, and MPC3 cells, respectively[1].

[1]. Del Poeta M, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8.