Naloxone methiodide 是一种外周限制性、非选择性和竞争性阿片受体 (opioid receptor) 拮抗剂。Naloxone methiodide 不能穿透血脑屏障。
货号:ajcx36162
CAS:93302-47-7
分子式:C20H24INO4
分子量：469.31
溶解度:DMSO : 250 mg/mL (532.70 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier[1][2].

Naloxone‐methiodide (10 mg/mL; 200 μL; i.p.), induces abdominal hypersensitivity in IL-10-/- mice with colitis[2].

[1]. Basso L, et al. TRPV1 promotes opioid analgesia during inflammation. Sci Signal. 2019;12(575):eaav0711. Published 2019 Apr 2. [2]. Basso L, et al. Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice. Neurogastroenterol Motil. 2020;32(2):e13743.