DCLX069 是一种选择性蛋白精氨酸甲基转移酶 1 (PRMT1) 抑制剂，IC50 值为 17.9 µM。DCLX069 对 PRMT4 和 PRMT6 的活性较低。DCLX069 具有抗癌作用。
货号:ajcx36114
CAS:792946-69-1
分子式:C20H25N3O2
分子量：339.43
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].

DCLX069 (12.5-100 µM) effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines (MCF7, HepG2, and THP1 cells) in a concentration-dependent manner[1].

[1]. Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73.