NCGC00029283 是一种 werner 综合征解旋酶-核酸酶 (WRN) 抑制剂，对 WRN、BLM 和 FANCJ 解旋酶的 IC50 分别为 2.3 μM、12.5 μM 和 3.4 μM。
货号:ajcx36096
CAS:714240-31-0
分子式:C18H12FN3O3
分子量：337.3
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].

NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].

[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.