| 规格: | 98% |
| 分子量: | 218.7 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
Clofibric acid-d4is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50= 50 µM in a transactivation assay) and the active metabolite of clofibrate .1It is formed from clofibrate by tissue and serum esterases.2Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.3It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L.4Clofibric acid has been found in wastewater effluent.5
1.Giampietro, L., Laghezza, A., Cerchia, C., et al.Novel phenyldiazenyl fibrate analogues as PPAR α/γ/δ pan-agonists for the amelioration of metabolic syndromeACS Med. Chem. Lett.10(4)545-551(2019) 2.Cayen, M.N.Metabolic disposition of clofibrateDrug Metabol. Drug Interact.3(1 & 2)77-103(1980) 3.Cayen, M.N., Ferdinandi, E.S., Greselin, E., et al.Clofibrate and clofibric acid: Comparison of the metabolic disposition in rats and dogsJ. Pharmacol. Exp. Ther.200(1)33-43(1977) 4.Saravanan, M., Karthika, S., Malarvizhi, A., et al.Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: Hematological, biochemical, ionoregulatory and enzymological responsesJ. Hazard. Mater.195188-194(2011) 5.Tixier, C., Singer, H.P., Oellers, S., et al.Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface watersEnviron. Sci. Technol.37(6)1061-1068(2003)
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