EN523 是 OTUB1 招募者。EN523 靶向 K48 泛素特异性去泛素酶 OTUB1 中的非催化变构半胱氨酸 C23。
货号:ajcx38924
CAS:2094893-05-5
分子式:C12H14N2O3
分子量:234.25
溶解度:DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:
现货Background:
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].
[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.