KJ-Pyr-9 is a MYC inhibitor (Kd = 6.5 nM) that interferes with Myc-Max complex formation in cells. Targeting of MYC can sensitize MM cells and provide rationale for inhibition of MYC and PAK as a novel combinatory regimen for the treatment of this otherwise therapy-resistant, clinically incurable malignancy. References: Tan Y, Sementino E, Chernoff J, Testa JR. Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. Am J Cancer Res. 2017 Aug 1;7(8):1724-1737. eCollection 2017. PubMed PMID: 28861328; PubMed Central PMCID: PMC5574944.

纯度：≥98%

CAS：581073-80-5