GYKI-53405, formerly known as LY 293606, is a noncompetitive AMPA receptor antagonist. GYKI-53405 binds specifically to Xenopus brain membranes with KD and Bmax values of 4.5 microM and 35 pmol mg-1 protein respectively. Binding is increased in the presence of Mg2+ and is unaffected by AMPA or kainate. References: Jakus R, Graf M, Ando RD, Balogh B, Gacsalyi I, Levay G, Kantor S, Bagdy G. Effect of two noncompetitive AMPA receptor antagonists GYKI 52466 and GYKI 53405 on vigilance, behavior and spike-wave discharges in a genetic rat model of absence epilepsy. Brain Res. 2004 May 22;1008(2):236-44. PubMed PMID: 15145761.

纯度：≥98%

CAS：143691-37-6