T-3364366 is a potent, reversible, slow-binding D5D inhibitor with D5D Ki < 2.7 nM and a dissociation half-life in excess of 2.0 h. The long residence time was confirmed in cellular washout assays. Delta-5 desaturase (D5D) catalyzes the conversion from dihomo-gamma linoleic acid (DGLA) to arachidonic acid (AA). DGLA and AA are common precursors of anti- and pro-inflammatory eicosanoids, respectively, making D5D an attractive drug target for inflammatory-related diseases. References:

纯度：≥98%

CAS：1356354-09-0