| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | CC(C)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CCCCCCCCCCCCC)=O)=O)=O)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O.OC(C(F)(F)F)=O |
| 分子式 | C90H154N30O17·XCF3COOH |
| 分子量 | 1928.4 |
| 溶解度 | Water: 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Myr-ZIP is a cell-permeable inhibitor of the constitutively active protein kinase C (PKC) isoform PKMζ (Ki= 0.076-2.11 µM).1,2It also inhibits PKCα when used at a concentration of 10 µM.3Myr-ZIP (5 µM) prevents PKC translocation to the plasma membrane induced by ionomycin in HEK293 cells expressing A-kinase anchor protein 79 (AKAP79). Myr-ZIP inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0.5 µl per side.4 1.Yao, Y., Shao, C., Jothianandan, D., et al.Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neuronsNeuropharmacology64(1)37-44(2013) 2.Lee, A.M., Kanter, B.R., Wang, D., et al.Prkcz null mice show normal learning and memoryNature493(7432)419-419(2013) 3.Bogard, A.S., and Tavalin, S.J.Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocationMol. Pharmacol.88(4)728-735(2015) 4.Li, Y.-q., Xue, Y.-x., He, Y.-y., et al.Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memoryJ. Neurosci.31(14)5436-5446(2011) |
m.cnreagent.com