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NRX-2663
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NRX-2663图片
CAS NO:2763260-34-8
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
NRX-2663 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 β-catenin 与 β-TrCP 的结合，EC50 为 22.9 ?M，Kd 为 54.8 nM。
Cas No.2763260-34-8
分子式C20H13F3N2O5
分子量418.32
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

[1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.