| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)).
Cell lines | PC12 cells |
Preparation Method | Two days after plating cell were treated with different concentrations of aged β12-28 peptide. After 22 h, MTT (5 mg/ml) was added and incubation was continued for a further2 h. Cells were lysed and after 24 h at 37°C, colorimetric determination of MTT reduction was made at 550 nm. |
Reaction Conditions | 0.001, 0.1, 10, 40 µM for 22 hours |
Applications | Freshly pre-pared solutions of β12 - 28 were non-toxic as expected, while aged solutions produce generally significant decreases in the MTT mitochondrial reduction by PC12 cells. |
| 产品描述 | Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42))[1]. One of the neuropathological features of Alzheimer's disease (AD) is the presence of amyloid deposits in senile plaques and in blood vessel walls[2]. Amyloid Beta-Peptide (12-28) was used as an internal standard[1]. Amyloid Beta-Peptide (12-28) (human) could efficiently suppress the formation of the α7nAChR.Aβ (1-42) complex. Using human brain tissues and cells that overexpress either the α7 nicotinic acetylcholine receptor (α7nAChR) or amyloid precursor protein as the starting material, Aβ (1-42) and α7nAChR can be co-immunoprecipitated by the respective specific antibodies, suggesting that they are tightly associated[3]. References: |
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