| CAS NO: | 153436-54-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 153436-54-5 |
| 别名 | 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉,SU-5271; AG1517; ZM 252868 |
| Canonical SMILES | COC(C(OC)=C1)=CC2=C1N=CN=C2NC3=CC(Br)=CC=C3 |
| 分子式 | C16H14BrN3O2 |
| 分子量 | 360.2 |
| 溶解度 | DMF: 0.3 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml,Ethanol: 0.2 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki= 5.2 pM; IC50= 29 pM).1It less effectively inhibits HER2 (IC50= 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases.1PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.2,3 1.Fry, D.W., Kraker, A.J., McMichael, A., et al.A specific inhibitor of the epidermal growth factor receptor tyrosine kinaseScience265(5175)1093-1095(1994) 2.Bos, M., Mendelsohn, J., Kim, Y.M., et al.PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent mannerClinical Cancer Research3(11)2099-2106(1997) 3.Rae, J.M., and Lippman, M.E.Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitorsBreast Cancer Research and Treatment83(2)99-107(2004) |
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