Bazedoxifene-d4

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Bazedoxifene-d4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1133695-49-4

包装与价格：

包装	价格(元)
500 μg	电议
1mg	电议

产品介绍

巴多昔芬-d4 是氘标记的巴多昔芬。 Bazedoxifene (TSE-424) 是一种口服的、可渗透 BBB 的非甾体选择性雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 的 IC50 分别为 23 nM 和 99 nM。巴多昔芬可用于骨质疏松症的研究。 Bazedoxifene 还作为 IL-6/GP130 蛋白-蛋白相互作用的抑制剂，可用于胰腺癌的研究。

Cas No.	1133695-49-4
别名	1-[[4-[2-(六氢-1H-氮杂卓-1-基)乙氧基-1,1,2,2-D4]苯基]甲基]-2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇,TSE-424-d4
Canonical SMILES	CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OC([2H])([2H])C([2H])([2H])N4CCCCCC4)C=C3)C5=C1C=C(O)C=C5
分子式	C₃₀H₃₀D₄N₂O₃
分子量	474.6
储存条件	Store at 2°C to 8°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Bazedoxifene-d₄is intended for use as an internal standard for the quantification of bazedoxifene by GC- or LC-MS. Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC₅₀= 26 nM) and ERβ (IC₅₀= 99 nM).¹Bazedoxifene antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferationin vitroas well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).²It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα. 1.Komm, B.S., Kharode, Y.P., Bodine, P.V.N., et al.Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivityEndocrinology146(9)3999-4008(2005) 2.Lewis-Wambi, J.S., Kim, H., Curpan, R., et al.The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1Mol. Pharmacol.80(4)610-620(2011)