| CAS NO: | 172669-64-6 |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1 g | 电议 |
| 5 g | 电议 |
| 10 g | 电议 |
| Cas No. | 172669-64-6 |
| 别名 | 甘氨酰-L-谷氨酰胺 |
| Canonical SMILES | NC(CC[C@H](NC(CN)=O)C(O)=O)=O.O |
| 分子式 | C7H13N3O4• H2O |
| 分子量 | 221.2 |
| 溶解度 | Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Glycyl-L-glutamine is a C-terminal dipeptide fragment of β-endorphin .1It decreases reperfusion damage and increases the time to ischemic contracture in isolated rat hearts in a model of cardiac ischemia-reperfusion injury using eight- and 36-week old rats when used at a concentration of 5 mM.2Glycyl-L-glutamine (1-100 nmol) inhibits morphine-induced respiratory depression with no effect on morphine-induced analgesia in rats.3It also inhibits acquisition of place preference, delays the development of tolerance, and reduces withdrawal intensity in morphine-conditioned rats.4 1.Parish, D.C., Smyth, D.G., Normanton, J.R., et al.Glycyl glutamine, an inhibitory neuropeptide derived from β-endorphinNature306(5940)267-270(1983) 2.Almashhadany, A., Alghamdi, O.A., Van der Touw, T., et al.?-Glycyl-?-glutamine provides the isolated and perfused young and middle-aged rat heart protection against ischaemia-reperfusion injuryAmino Acids47(8)1559-1565(2015) 3.Owen, M.D., Unal, C.B., Callahan, M.F., et al.Glycyl-glutamine inhibits the respiratory depression, but not the antinociception, produced by morphineAm. J. Physiol. Regul. Integr. Comp. Physiol.279(5)R1944-R1948(2000) 4.Cavun, S., GÖktalay, G., and Millington, W.R.Glycyl-glutamine, an endogenous β-endorphin-derived peptide, inhibits morphine-induced conditioned place preference, tolerance, dependence, and withdrawalJ. Pharmacol. Exp. Ther.315(2)949-958(2005) |
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