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VX-150
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VX-150图片
CAS NO:1793080-72-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
VX-150 是一种具有口服活性的，高选择性 NaV1.8 抑制剂。VX-150 具有用于各种疼痛适应症研究的潜力。
Cas No.1793080-72-4
别名N-[1,2-二氢-2-氧代-1-[(膦酰氧基)甲基]-4-吡啶基]-2-(4-氟-2-甲基苯氧基)-4-(三氟甲基)苯甲酰胺
分子式C21H17F4N2O7P
分子量516.34
溶解度DMSO : 125 mg/mL (242.09 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold)[1].

[1]. Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.