AS-1411 (AS1411) is a novel and potent quadruplex-forming oligonucleotide aptamer quadruplex-forming oligonucleotide aptamer with antitumor activity. It acts by targeting nucleolin. It is currently in clinical trials as a treatment for various cancers. AS1411 causes relocalization of the nucleolin-PRMT5 complex from the nucleus to the cytoplasm. Consequently, the nuclear activity of PRMT5 is decreased, leading to derepression of some PRMT5 target genes, which may contribute to the biological effects of AS1411.

纯度：≥98%

CAS：301636-59-9