| CAS NO: | 6066-49-5 |
| 包装: | 50mg |
| 市场价: | 1124元 |
| Cas No. | 6066-49-5 |
| 别名 | 丁基苯酞; 3-n-Butylphthalide; 3-Butylphthalide |
| 化学名 | 3-butyl-3H-2-benzofuran-1-one |
| Canonical SMILES | CCCCC1C2=CC=CC=C2C(=O)O1 |
| 分子式 | C12H14O2 |
| 分子量 | 190.24 |
| 溶解度 | ≥ 19mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.IC50 value:Target:3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [2]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain [4]. References: |
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